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    Question

    The vitamin B deficiency will lead to the accumulation

    of which of the following metabolites?
    A Pyruvic acid Correct Answer Incorrect Answer
    B Methyl malonic acid Correct Answer Incorrect Answer
    C α‐Keto glutarate Correct Answer Incorrect Answer
    D Biotin Correct Answer Incorrect Answer

    Solution

    Vitamin B12 (cobalamin) is essential for the conversion of methylmalonyl-CoA to succinyl-CoA. In vitamin B12 deficiency, this conversion is impaired, leading to the accumulation of methylmalonic acid. Therefore, elevated levels of methylmalonic acid are indicative of vitamin B12 deficiency.

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