Question
Which gene mutation was discovered by Mary Brunkow and
Fred Ramsdell in 2001 linked to autoimmune diseases?Solution
In 2001, Mary Brunkow and Fred Ramsdell discovered that a mutation in the Foxp3 gene caused autoimmune disease in both mice and humans. This finding directly linked genetic mutation to immune regulation failure and contributed to understanding regulatory T cells identified earlier by Sakaguchi.
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