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    Question

    Which gene mutation was discovered by Mary Brunkow and

    Fred Ramsdell in 2001 linked to autoimmune diseases?
    A p53 Correct Answer Incorrect Answer
    B Foxp3 Correct Answer Incorrect Answer
    C BRCA1 Correct Answer Incorrect Answer
    D HLA-DQ2 Correct Answer Incorrect Answer
    E CD28 Correct Answer Incorrect Answer

    Solution

    In 2001, Mary Brunkow and Fred Ramsdell discovered that a mutation in the Foxp3 gene caused autoimmune disease in both mice and humans. This finding directly linked genetic mutation to immune regulation failure and contributed to understanding regulatory T cells identified earlier by Sakaguchi.

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