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The given sentence talks about a person who, when in a particular place or state, thinks too much about space to the extent of feeling as if his/her brain is going to explode. The blank requires a noun to describe that state. Among the given options, the pair of 'isolation' and 'solitariness' fits in the blank appropriately. 'Isolation' means the state of being detached or separated. 'Solitariness' means the state of being in solitude. Hence, (b) is the correct answer. Option (a) is negated because 'alone' is an adjective. Option (c) is negated because 'protecting' is a verb. Option (d) is negated because 'remote' is an adjective; its noun meaning won't be relevant in the given context. Option (e) is negated because 'friendly' is an adjective.
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