In the question below, two sentences are given and each of them consists of two words highlighted in bold. The words may be incorrectly placed and need to be interchanged in order to make both the sentences contextually correct. From the options, choose the option that represents the correct combination of the words that need to be interchanged.
I. It is universally accepted that poor (1) efficacy and hygiene are a major cause of disease in (2) regulatory countries.
II. If a vaccine's safety and (3) sanitation are looking good, it will be submitted to (4) developing agencies for full approval.  

I - We need a noun in 1 to be modified by the adjective POOR. In 2, we need an adjective to modify the noun COUNTRIES. The sentence says that it is a well-known fact that low standards of cleanliness and hygiene are a major cause of diseases in underdeveloped countries. Although EFFICACY (efficiency) and REGULATORY (governing) fit structurally, they are contextually inappropriate for 1 and 2, respectively. EFFICACY should be replaced with SANITATION (cleanliness) and REGULATORY should be replaced with DEVELOPING (not yet developed). II - The sentence says that once a vaccine candidate is proven safe and effective, it is submitted to authorised agencies for full approval. Although SANITATION fits structurally, it is not an attribute of a vaccine. It should be replaced with EFFICACY. Similarly, DEVELOPING, which fits structurally, is not an appropriate adjective for agencies that monitor the creation of vaccines. It should be replaced with REGULATORY.