In the question below, two sentences are given and each of them consists of two words highlighted in bold. The words may be incorrectly placed and need to be interchanged in order to make both the sentences contextually correct. From the options, choose the option that represents the correct combination of the words that need to be interchanged.
I. It is universally accepted that poor (1) efficacy and hygiene are a major cause of disease in (2) regulatory countries.
II. If a vaccine's safety and (3) sanitation are looking good, it will be submitted to (4) developing agencies for full approval.