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      Question

      A novel small molecule, designed and synthesised by

      Indian researchers, has shown promise in targeted killing of cancer cells. The molecule (Disarib) works by binding itself to a protein called BCL2. While BCL2 protein is produced in excess in cancer cells, its expression is almost undetectable in normal cells. ………………………………………. Inside a cell there is always a balance between proteins that promote cell death (apoptosis) and those that suppress cell death. In each of these questions, a paragraph is given that has blank in it. Five sentences (1), (2), (3), (4) and (5) are suggested. Out of these, only one fits the blank in the context of the paragraph. Pick that sentence as the answer.
      A A team demonstrated that Disarib was able to disrupt the interaction of BCL2 and apoptosis – causing BAK protein and cause the death of cancer cells. Correct Answer Incorrect Answer
      B However, expression of BCL2 is low in certain cancer cell lines such as breast cancer, chronic myelogenous leukaemia and cervical cancer. Correct Answer Incorrect Answer
      C Hence, Disarib targets and kills only cancer cells while sparing normal cells. Correct Answer Incorrect Answer
      D So the Disarib molecule would be ineffective in these cancers. Correct Answer Incorrect Answer
      E Studies were carried out on three animal models for three different cancers- lymphoma, breast adenocarcinoma and ovarian cancer. Correct Answer Incorrect Answer

      Solution

      Option 3 is in continuation with the previous statement and talks about the Disarib molecule and its activity and function. Therefore fits most appropriately.

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